According to the immunologists at the Weizmann Institute of Science, Israel, artificial sweeteners may interrupt with the body’s capacity to standardize blood sugar as it changes the metabolism of body than can be antecedent to diabetes.
Number of experiments were conducted on mice and it was seen that sweeteners amend the microbiome i.e the microbes which are present in the digestive system. Various combinations of microbes change the metabolism of glucose which leads to higher levels of glucose after eating and to regress slowly than it normally should.
Many complaints such as diabetes and obesity are linked to changes in combination of microbiome.
There are certain contradictory statements regarding use of artificial sweeteners like according to one study, using sweetener may help in weight loss while the other suggests that it was just the contrary. But it is still advisable to stay away from the use of sweetner.